
Retatrutide
Retatrutide is a synthetic triple-receptor agonist peptide synthesised as a GIP, GLP-1, and glucagon receptor agonist, studied in Eli Lilly Phase 2/3 metabolic research for its role in combined GIP, GLP-1, and glucagon receptor activation.
A triple agonist peptide targeting GIP, GLP-1, and glucagon receptors — studied in advanced metabolic and weight-regulation contexts.
Subscribe & save — €165 on recurring 60-day delivery. Configured at checkout.
- Availability
- Ships within 1 business day
- Storage
- Store 2–8 °C. Reconstitute before use.
- Ships from
- European fulfilment centre, cold-chain express
Lab proof, by batch
- Tested independently, by batch
- Certificate of analysis available
- Purity and identity on record
Triple Receptor Agonist Research.
Retatrutide (CAS 2381089-83-2) combines GIP, GLP-1, and glucagon receptor activation in a single sequence. Phase 2 clinical trials have reported substantial reductions in body weight and improvements in metabolic markers. Formula C223H341N57O64S, MW 4858.60 g/mol. Strict clinical guidance required.
- — Jastreboff et al. — Phase 2 trial of Retatrutide: dose-dependent weight-loss endpoints
- — Coskun et al. — GIP/GLP-1/glucagon tri-agonism and energy expenditure markers
Research context only. Not medical advice. Consult a qualified clinician before use.
- 5 mg lyophilised powder per vial
- Reconstitute with bacteriostatic water before use
- Store lyophilised at 2–8 °C, keep from light
- Once reconstituted, refrigerate and use within 28 days
- One 5 mg lyophilised Retatrutide vial
- Tamper-evident cap with batch-coded label
- Storage and clinician-consultation card
What the research reports about this molecule.
Classic parameters from peer-reviewed literature. Not human dosing guidance — read alongside the PubMed references on /learn.
- Sequence
- Triple GIP/GLP-1/glucagon receptor agonist
- Mechanism
- Activates GIP, GLP-1, and glucagon receptors
- Research domain
- Metabolic, weight regulation (Eli Lilly Phase 2/3)
- Reconstitution
- Bacteriostatic water, USP
- Storage
- Long-term -20°C lyophilised; -80°C for >12 months; reconstituted 2-8°C, ≤4 weeks
Simple, deliberate steps — not a protocol.
These are practical handling notes. Dosing decisions stay between you and your clinician.
- 1
Reconstitute under clinical guidance — dose titration from a low starting dose is essential
- 2
Administer subcutaneously as directed; follow the prescribed dose escalation schedule
- 3
Refrigerate reconstituted vial; use within 28 days
How-to-use guide
Read the research protocol
Concise reconstitution, dosing, and handling instructions.
Each release is matched with quality documentation through a documented verification path. Identity, purity, and composition test results sit on the product page before you buy.
Every batch is verified by an ISO/IEC 17025-accredited laboratory before release. Identity, purity, and documentation travel with the product — not behind a form.
Sensitive peptides ship in insulated insulated cold packaging with gel packs sized for a 48-hour transit window, tracked door to door.
Everything worth asking before you order.
Shipping, storage, quality, and when to speak to a clinician — without the runaround.
What proof of quality comes with my order?
Every batch ships with a batch code printed on the vial. The matching independent lab report — identity, purity, and composition — independently lab-tested results — is linked on the product page and also available from your order page after purchase.
Should I speak to a clinician before using a peptide?
We recommend it — especially if you are pregnant, nursing, managing a medical condition, or combining peptides with prescribed medication. Our product pages are educational. They are not medical advice and they do not replace a conversation with a qualified practitioner.
When will my order ship and arrive?
Orders placed before 14:00 CET Monday–Friday ship the same business day from our European fulfilment centre in The Hague, Netherlands. Standard tracked EU delivery arrives in 2–4 business days; express options are available at checkout.
What does "research only" actually mean on a peptide label?
Research-only means the compound has not been approved by the EMA or any national medicines authority for medical use, and is sold solely for in-vitro and laboratory research. It is not a supplement, a cosmetic, or a medicine, and it carries no claims for human consumption.
Is retatrutide approved or available as a medicine?
No. Retatrutide is a triple agonist of GLP-1, GIP, and glucagon receptors developed by Eli Lilly and currently in Phase 3 trials (TRIUMPH programme). It is not approved by the EMA or FDA, so it cannot be prescribed. Phase 2 data showed up to ~24 percent body-weight reduction at 48 weeks.
What are the most common side effects of GLP-1 peptides specifically?
Across SUSTAIN, SURPASS, SURMOUNT, and TRIUMPH trials, the dominant adverse events for semaglutide, tirzepatide, and retatrutide are gastrointestinal: nausea, vomiting, diarrhoea, constipation, and abdominal discomfort, usually mild-to-moderate and concentrated during dose titration.
What's the difference between a prescription peptide and a research peptide?
A prescription peptide (e.g. Wegovy, Mounjaro, Vyleesi, Zadaxin in the relevant jurisdictions) has been through EMA or national-authority review, carries an authorised indication, and is dispensed by a pharmacy against a script. A research peptide is a reference-grade compound sold for laboratory use only.
How do I reconstitute a lyophilised peptide vial?
Bring both the lyophilised vial and the bacteriostatic water to room temperature, equalise pressure with a sterile vented needle, then inject the solvent slowly down the side of the vial. Swirl gently — never shake — until clear, and refrigerate at 2–8 °C.
How much bacteriostatic water should I add to my peptide vial?
The calculation is peptide mass (mg) ÷ desired concentration (mg/mL) = volume of bacteriostatic water in mL. For example, a 5 mg vial at 1 mg/mL needs 5 mL; at 2 mg/mL, 2.5 mL. Every Peptyds product page carries a suggested reconstitution volume tuned to the vial size.
How long does a reconstituted peptide stay stable in the fridge?
Most lyophilised peptides reconstituted with bacteriostatic water remain stable for 28–30 days at 2–8 °C, protected from light. A handful of short, fragile sequences — Epithalon among them — drop to roughly 14 days. Never freeze a reconstituted vial.
What side effects are most commonly reported across peptide research?
Across published trials and case series, the most frequent reported events are injection-site reactions (redness, induration, transient discomfort), headache, mild nausea, and temporary fatigue. GLP-1 and dual-agonist class peptides add dose-dependent gastrointestinal effects.
Who should not use peptides?
Peptides are not appropriate for anyone who is pregnant, nursing, planning conception, under 18, managing active cancer, or on immunosuppressants — and competitive athletes governed by WADA must avoid every peptide on the prohibited list. Anyone with a personal or family history of melanoma should specifically avoid melanocortin-receptor agonists.