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5 mg vial lyophilised vial of MOTS-c, ISO/IEC 17025 lab-verified, Peptyds packaging
Vitality Systems
Vital
MOTS-c
Mitochondrial Metabolic Research
Third-party tested≥ 98% lab-verified purity
A mitochondria-derived peptide studied for its role in metabolic regulation, insulin sensitivity, and cellular energy homeostasis — an emerging longevity-pathway molecule.
Vitality Systems

MOTS-c

MOTS-c is a mitochondrial-derived peptide of 16 amino acids encoded within the 12S rRNA region of mitochondrial DNA, studied in metabolic and ageing research for its role in regulating AMPK signalling and glucose homeostasis.

A mitochondria-derived peptide studied for its role in metabolic regulation, insulin sensitivity, and cellular energy homeostasis — an emerging longevity-pathway molecule.

Third-party tested≥ 98% lab-verified purityShips cold-chain
Size
€5620 mg · Incl. VAT

Single email when this batch is back. No marketing list, no follow-ups.

Availability
Ships within 1 business day
Storage
Store 2–8 °C. Reconstitute before use.
Ships from
European fulfilment centre, cold-chain express

Lab proof, by batch

  • Tested independently, by batch
  • Certificate of analysis available
  • Purity and identity on record
What this peptide is for

Mitochondrial Metabolic Research.

MOTS-c (CAS 1627580-64-6) is a 16-amino-acid peptide encoded within mitochondrial 12S rRNA. Research has examined its role in AMPK activation, skeletal muscle glucose uptake, and age-related metabolic decline reversal in preclinical models. Formula C121H200N42O22S2, MW 2174.71 g/mol.

Linked research
  • Lee et al. — MOTS-c, AMPK pathway activation, and insulin sensitivity
  • Reynolds et al. — mitochondria-derived peptides and age-related metabolic decline reversal

Research context only. Not medical advice. Consult a qualified clinician before use.

Specification
  • 5 mg lyophilised powder per vial
  • Reconstitute with bacteriostatic water before use
  • Store lyophilised at 2–8 °C, protect from light
  • Once reconstituted, refrigerate and use within 14 days
What arrives in the box
  • One 5 mg lyophilised MOTS-c vial
  • Tamper-evident cap with batch-coded label
  • Storage and reconstitution card
Pharmacology

What the research reports about this molecule.

Classic parameters from peer-reviewed literature. Not human dosing guidance — read alongside the PubMed references on /learn.

Sequence
16-amino-acid mitochondrial-derived peptide
Molecular weight
1700 Da
Mechanism
Regulates AMPK signalling and glucose homeostasis
Research domain
Metabolic, ageing
Reconstitution
Bacteriostatic water, USP
Storage
Long-term -20°C lyophilised; -80°C for >12 months; reconstituted 2-8°C, ≤4 weeks
How to use

Simple, deliberate steps — not a protocol.

These are practical handling notes. Dosing decisions stay between you and your clinician.

  1. 1

    Reconstitute with 1 mL bacteriostatic water — swirl gently

  2. 2

    Administer subcutaneously or IV as directed by your clinician

  3. 3

    Refrigerate reconstituted vial; use within 14 days

How-to-use guide

Read the research protocol

Concise reconstitution, dosing, and handling instructions.

Quality documentation
Batch-by-batch lab verification

Each release is matched with quality documentation through a documented verification path. Identity, purity, and composition test results sit on the product page before you buy.

Quality documentation
ISO/IEC 17025-accredited lab testing

Every batch is verified by an ISO/IEC 17025-accredited laboratory before release. Identity, purity, and documentation travel with the product — not behind a form.

Storage & shipping
Kept-cold commitment

Sensitive peptides ship in insulated insulated cold packaging with gel packs sized for a 48-hour transit window, tracked door to door.

Questions, answered plainly

Everything worth asking before you order.

Shipping, storage, quality, and when to speak to a clinician — without the runaround.

What proof of quality comes with my order?

Every batch ships with a batch code printed on the vial. The matching independent lab report — identity, purity, and composition — independently lab-tested results — is linked on the product page and also available from your order page after purchase.

How much scientific detail is on each product page?

Each page opens with a clear purpose line line and the testing behind it, then expands into research notes, dosing specifications, and linked peer-reviewed studies for readers who want more depth. You decide how deep you go.

When will my order ship and arrive?

Orders placed before 14:00 CET Monday–Friday ship the same business day from our European fulfilment centre in The Hague, Netherlands. Standard tracked EU delivery arrives in 2–4 business days; express options are available at checkout.

Why do clinics use NAD+ injections instead of NAD+ capsules?

Oral NAD+ is poorly absorbed intact, so most oral supplements use precursors — NR (nicotinamide riboside) or NMN (nicotinamide mononucleotide) — which the body converts to NAD+. Subcutaneous and IV NAD+ bypass first-pass metabolism and produce measurable plasma elevations in published pharmacokinetic work.

Are peptides safe long-term?

Honestly: it depends on the molecule. EMA-approved peptide drugs (semaglutide, tirzepatide, tesamorelin, thymalfasin in some jurisdictions) have multi-year safety datasets. Unapproved research peptides — BPC-157, TB-500, Melanotan II, Epithalon — have limited or no long-term human data.

How do I reconstitute a lyophilised peptide vial?

Bring both the lyophilised vial and the bacteriostatic water to room temperature, equalise pressure with a sterile vented needle, then inject the solvent slowly down the side of the vial. Swirl gently — never shake — until clear, and refrigerate at 2–8 °C.

How much bacteriostatic water should I add to my peptide vial?

The calculation is peptide mass (mg) ÷ desired concentration (mg/mL) = volume of bacteriostatic water in mL. For example, a 5 mg vial at 1 mg/mL needs 5 mL; at 2 mg/mL, 2.5 mL. Every Peptyds product page carries a suggested reconstitution volume tuned to the vial size.

How long does a reconstituted peptide stay stable in the fridge?

Most lyophilised peptides reconstituted with bacteriostatic water remain stable for 28–30 days at 2–8 °C, protected from light. A handful of short, fragile sequences — Epithalon among them — drop to roughly 14 days. Never freeze a reconstituted vial.

What side effects are most commonly reported across peptide research?

Across published trials and case series, the most frequent reported events are injection-site reactions (redness, induration, transient discomfort), headache, mild nausea, and temporary fatigue. GLP-1 and dual-agonist class peptides add dose-dependent gastrointestinal effects.

Who should not use peptides?

Peptides are not appropriate for anyone who is pregnant, nursing, planning conception, under 18, managing active cancer, or on immunosuppressants — and competitive athletes governed by WADA must avoid every peptide on the prohibited list. Anyone with a personal or family history of melanoma should specifically avoid melanocortin-receptor agonists.