KPV
KPV is a tripeptide of 3 amino acids (Lys-Pro-Val) derived from the C-terminus of alpha-MSH, studied in enterocolitis and dermal inflammation research for its role in suppressing NF-κB, TNF-α, and IL-1β signalling.
An alpha-MSH-derived tripeptide studied for its anti-inflammatory properties across gut, skin, and systemic inflammatory signalling pathways.
- Availability
- Ships within 1 business day
- Storage
- Store 2–8 °C. Reconstitute before use.
- Ships from
- European fulfilment centre, cold-chain express
Lab proof, by batch
- Tested independently, by batch
- Certificate of analysis available
- Purity and identity on record
Anti-Inflammatory Peptide Research.
KPV (Lys-Pro-Val, CAS 867021-83-8) is a C-terminal fragment of alpha-MSH with documented anti-inflammatory activity via NF-κB inhibition and cytokine modulation. Research has examined its effects on inflammatory bowel disease models, skin inflammation, and wound healing. Formula C18H34N6O4, MW 398.50 g/mol.
- — Dalmasso et al. — KPV and NF-κB pathway inhibition in colitis models
- — Brzoska et al. — alpha-MSH tripeptides in skin inflammation and wound repair
Research context only. Not medical advice. Consult a qualified clinician before use.
- 5 mg lyophilised powder per vial
- Reconstitute with bacteriostatic water before use
- Store lyophilised at 2–8 °C, protect from light
- Once reconstituted, refrigerate and use within 30 days
- One 5 mg lyophilised KPV vial
- Tamper-evident cap with batch-coded label
- Storage card with reconstitution guidance
What the research reports about this molecule.
Classic parameters from peer-reviewed literature. Not human dosing guidance — read alongside the PubMed references on /learn.
- Sequence
- Tripeptide (Lys-Pro-Val)
- Molecular weight
- 372 Da
- Mechanism
- Suppresses NF-κB, TNF-α, IL-1β signalling
- Research domain
- Enterocolitis, dermal inflammation
- Reconstitution
- Bacteriostatic water, USP
- Storage
- Long-term -20°C lyophilised; -80°C for >12 months; reconstituted 2-8°C, ≤4 weeks
Simple, deliberate steps — not a protocol.
These are practical handling notes. Dosing decisions stay between you and your clinician.
- 1
Reconstitute with 2 mL bacteriostatic water — swirl gently
- 2
Administer as directed by your clinician — route depends on target tissue
- 3
Refrigerate reconstituted vial; use within 30 days
How-to-use guide
Read the research protocol
Concise reconstitution, dosing, and handling instructions.
Each release is matched with quality documentation through a documented verification path. Identity, purity, and composition test results sit on the product page before you buy.
Every batch is verified by an ISO/IEC 17025-accredited laboratory before release. Identity, purity, and documentation travel with the product — not behind a form.
Sensitive peptides ship in insulated insulated cold packaging with gel packs sized for a 48-hour transit window, tracked door to door.
Everything worth asking before you order.
Shipping, storage, quality, and when to speak to a clinician — without the runaround.
What proof of quality comes with my order?
Every batch ships with a batch code printed on the vial. The matching independent lab report — identity, purity, and composition — independently lab-tested results — is linked on the product page and also available from your order page after purchase.
How should I store my order when it arrives?
Sensitive peptides ship cold. Move them to a fridge on arrival (2–8 °C) unless the product page states otherwise. Lyophilised vials can tolerate short transit at ambient temperature but should not be left unrefrigerated for extended periods once delivered.
When will my order ship and arrive?
Orders placed before 14:00 CET Monday–Friday ship the same business day from our European fulfilment centre in The Hague, Netherlands. Standard tracked EU delivery arrives in 2–4 business days; express options are available at checkout.
How do I reconstitute a lyophilised peptide vial?
Bring both the lyophilised vial and the bacteriostatic water to room temperature, equalise pressure with a sterile vented needle, then inject the solvent slowly down the side of the vial. Swirl gently — never shake — until clear, and refrigerate at 2–8 °C.
How much bacteriostatic water should I add to my peptide vial?
The calculation is peptide mass (mg) ÷ desired concentration (mg/mL) = volume of bacteriostatic water in mL. For example, a 5 mg vial at 1 mg/mL needs 5 mL; at 2 mg/mL, 2.5 mL. Every Peptyds product page carries a suggested reconstitution volume tuned to the vial size.
How long does a reconstituted peptide stay stable in the fridge?
Most lyophilised peptides reconstituted with bacteriostatic water remain stable for 28–30 days at 2–8 °C, protected from light. A handful of short, fragile sequences — Epithalon among them — drop to roughly 14 days. Never freeze a reconstituted vial.
What side effects are most commonly reported across peptide research?
Across published trials and case series, the most frequent reported events are injection-site reactions (redness, induration, transient discomfort), headache, mild nausea, and temporary fatigue. GLP-1 and dual-agonist class peptides add dose-dependent gastrointestinal effects.
Who should not use peptides?
Peptides are not appropriate for anyone who is pregnant, nursing, planning conception, under 18, managing active cancer, or on immunosuppressants — and competitive athletes governed by WADA must avoid every peptide on the prohibited list. Anyone with a personal or family history of melanoma should specifically avoid melanocortin-receptor agonists.